Drug design.

Edited by E.J. Ariëns.

Publisher: Academic Press in New York

Written in English
Published: Downloads: 612
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Subjects:

  • Pharmaceutical chemistry,
  • Pharmacology

Edition Notes

Includes bibliographies.

SeriesMedicinal chemistry; a series of monographs -- v. 11
ContributionsAriëns, E. J.
Classifications
LC ClassificationsRM300 D74
ID Numbers
Open LibraryOL18315368M

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book, and also. drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

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Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form).

Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. The Principles of Drug Design course aims to provide students with an understanding of the process of drug discovery and development from the identification of novel drug targets to the introduction of new drugs into clinical practice.

It covers the basic principles of how new drugs are discovered with. Drug Design 4th Edition by Dr. Kulkarni (Author), Dr. Bothara (Author) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

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The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of Edition: 1.

DRUG DESIGN: STRUCTURE- AND LIGAND-BASED APPROACHES Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are active areas of research in both the academic and commercial realms.

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Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures anReviews: 1. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery.

(This book is a printed edition of the Special Issue Molecular Modeling in Drug Design that was published in Molecules) Download PDF Add this book to My Library.

"In conclusion, this book provides a comprehensive introduction to computational drug design for scientists (e.g. medicinal chemists and pharmacologists, particularly at industrial level) who are not familiar with computational methods and who wish to discuss simulation outcomes with colleagues from computational departments.

Book Description. Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and information is presented in an up-to-date review form.

Book Description. The Organic Chemistry of Drug Design and Drug Action Third Edition represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and information is presented in an up-to-date review form Cited by: In this fifth edition of the Textbook of Drug Design and Discovery, readers are guided through the exciting, yet often complex world of modern medicinal ing with an introduction of general principles regarding chemical design and drug binding, the authors tackle difficult concepts in both physics and biochemistry in an easy to follow : J Huang.

The book follows drug design from the initial lead identification through Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine/5(3).

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. Drug Design, Discovery and Therapy: Clinical Trials and Regulatory Affairs.

Computer-aided drug design (CADD) has been credited to the modern patterns in compound characterization in drug discovery following its inception in This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology.

The aim of the book is to show how various facets of the drug discovery. India. In this book we have tried to provide a coherent and rational account of the principles underlying every aspect of drug design. Special chapters are devoted on Enzyme Inhibitors and Anti-Aids Agents to explain the strategy of the discovery and development of drugs.

Since theAuthor: Dr. V. M. KULKARNI, Dr. K. G. BOTHARA.Cambridge Core - Pharmacology - Drug Design - edited by Kenneth M. Merz, Jr.Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents.

New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more.